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KMID : 0358920100370030352
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Journal of the Korean Academy of Pedodontics
2010 Volume.37 No. 3 p.352 ~ p.358
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THE EFFECTS OF CHEMORADIATION THERAPY FOR NEUROBLASTOMA ON DENTAL CARIES ACTIVITY
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Lee Ji-Hyun
Park Ki-Tae
Sung Ki-Woong
Kim Ji-Yeon
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Abstract
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Chemotherapy or radiotherapy used for the treatment of pediatric cancer may have many adverse effects on the oral cavity. Oral mucositis, reduced salivary flow, oral infection, hypodontia, microdontia, arrested root development, and enamel hypoplasia are common oral complications. The aim of this study is to evaluate the effects of cancer therapy on dental caries activities. The children who had been treated for neuroblastoma in the department of pediatrics, Samsung Medical Center, were included and healthy children served as controls. The salivary flow rate, salivary buffering capacity, and Streptococcus mutans counts of both groups were evaluated using Dentocult SM and Dentobuff Strip. The dental caries activity related to the age at the start of treatment and the time elapsed since treatment completion were also evaluated. As a result, neuroblastoma patients had significantly lower salivary flow rate than the controls, while there were no significant differences between two groups as for salivary buffering capacity and Streptococcus mutans counts. The dental caries activities related to the age at the start of treatment and the time elapsed since treatment completion were not significantly different.
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KEYWORD
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Neuroblastoma, Dental caries activity, Salivary secretion rate, Salivary buffering capacity, Streptococcus mutans
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